What diseases cause subcutaneous nodules?
Only two storage diseases, multicentric reticulohistiocytosis and Farber disease, cause both subcutaneous nodules and arthritis. The bacterial pathogens producing nodules and arthritis include the treponemal organisms, syphilis, yaws, and pinta, as well as leprosy.
Why does sarcoidosis cause erythema nodosum?
Erythema nodosum is the most common nonspecific cutaneous lesion of sarcoidosis. 4 It represents a hypersensitivity reaction to a number of possible stimuli, including medications, infections, and inflammatory diseases.
How is erythema caused?
Erythema is a type of skin rash caused by injured or inflamed blood capillaries. It usually occurs in response to a drug, disease or infection. Rash severity ranges from mild to life threatening.
How can erythema nodosum be prevented?
There is no way to prevent erythema nodosum. Sometimes you can prevent the underlying cause, but since about half the cases of EN have no known cause (are idiopathic), there is no way to prevent it.
What causes skin nodules?
What causes lumps on the skin? Lumps can be on or underneath the skin. They may range from skin tags, lipoma (fatty deposits under the skin), cysts, warts, inflammatory acne, lymphoma (cancer of the lymph system), or skin cancer, including basal cell carcinoma, squamous cell carcinoma, or melanoma.
What do sarcoidosis lesions look like?
A rash of red or reddish-purple bumps, usually located on the shins or ankles, which may be warm and tender to the touch. Disfiguring sores (lesions) on the nose, cheeks and ears. Areas of skin that are darker or lighter in color. Growths under the skin (nodules), particularly around scars or tattoos.
What type of hypersensitivity is erythema nodosum?
Erythema nodosum (EN) is a delayed-type hypersensitivity reaction that most often presents as erythematous, tender nodules on the shins (picture 1A-D).
Does exercise help erythema nodosum?
In the meantime, however, the tenderness of the skin lesions may be alleviated by the following: Restriction of physical activity or bed rest. Elevation of the legs (if they are affected)
What causes erythema nodosum due to sarcoidosis?
Research scientists believe that Erythema Nodosum due to Sarcoidosis is caused by an immunological response of the body to sarcoidosis. The nodules form on skin as a reaction to the underlying condition. Currently, there are no known causes for sarcoidosis.
What is erythema nodosum?
Erythema nodosum happens when the layer of fat that everybody has under their skin becomes inflamed or irritated (panniculitis). Erythema nodosum is sometimes caused by some underlying disease or use of a medication, but about half the time there is no reason for it.
What is the relationship between erythema nodosum and tuberculosis (TB)?
Tuberculosis has long been linked with erythema nodosum. 1, 3, 9, 10 Erythema nodosum may occur with primary tuberculosis and may even manifest before the development of a skin-test reaction to tuberculin. The bacille Calmette-Guérin vaccination and the tuberculin skin test have been associated with the development of erythema nodosum.
What are the variants of erythema nodosum migrans (en)?
Erythema nodosum migrans, subacute nodular migratory panniculitis, and chronic erythema nodosum, disorders classically considered distinct from erythema nodosum, now are considered to be variants in the same disease spectrum.