Is benzimidazole a drug?
Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of …
What are examples of benzimidazole?
Those of interest are mebendazole, flubendazole, fenbendazole, oxfendazole, oxibendazole, albendazole, albendazole sulfoxide, thiabendazole, thiophanate, febantel, netobimin, and triclabendazole.
Which solvent is used for recrystallization in synthesis of benzimidazole?
Typical Procedure for the Preparation of Benzimidazoles If further purification was needed, by recrystallization it was dissolved in EtOH (10 mL) and then poured into ice water (30 mL).
Which are benzimidazole derivatives?
Benzimidazole derivatives, particularly ABZ and MBZ are well known for their anti-Giardia potency, particularly as compared with other drugs used for routine treatment of giardiasis (i.e. lower IC50 against trophozoites in vitro and lower ED50 in experimental infections).
What is benzimidazole made from?
Benzimidazole is produced by condensation of o-phenylenediamine with formic acid, or the equivalent trimethyl orthoformate: 2-substituted derivatives are obtained when the condensation is conducted with aldehydes in place of formic acid, followed by oxidation.
When was benzimidazole discovered?
1961
In 1961, Merck Sharp & Dohme Laboratories discovered 2-(thiazol-4-yl)benzimidazole (2, thiabendazole) as a broad-spectrum anthelmintic [3].
Is albendazole a benzimidazole?
Albendazole is a benzimidazole carbamate that has a broad spectrum of anthelmintic activity, including against Ascaris lumbricoides, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Echinococcus spp. and T. solium cysticerci.
What drug class is benzimidazole?
Benzimidazoles are often bioactive. Many anthelmintic drugs (albendazole, mebendazole, triclabendazole etc.) belong to the benzimidazole class of compounds.
Which acid is used in the synthesis of benzimidazole?
boric acid
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media.
What are the different reagents used in the synthesis of benzimidazole?
The synthesized benzimidazoles compounds were prepared from the condensation reaction between o-Phenylenediamine and various carbonyl compounds, in the presence of ammonium chloride as a catalyst.
Which acid is used for the synthesis of benzimidazole?
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes. This reaction led to the formation of benzimidazoles new derivatives in good yields.