What is an indican test?
The indican test is a quick and efficient screening exam that assays the possibility of dysbiosis using a patient’s urine. During occasions of overgrowth, bacteria intercept the amino acid tryptophan before it can be processed by the small intestine.
What is indican blood test?
The urinary Indican test is an accurate, simple, fast (15 min) and inexpensive screening tool for the identification of protein putrefaction in the gastrointestinal tract. Note: For research use only. Not intended for diagnostic use. (The Indican Reagent is corrosive.
What is the significance of indican?
Medical significance Normal urine reacting to hydrogen peroxide does at times produce a bluish tinge. Tryptophan is first converted to indole (excreted in faeces), then to indican by bacteria in the gut. Indican, being water-soluble, is then excreted through the urine.
What is the significance of indican in the urine?
Urinary indican, a metabolic product of bacterial action on tryptophan in the small bowel, has been estimated in the urine as an indirect indication of small bowel bacterial contamination, in 50 normal controls, 18 patients with small bowel disease, 22 patients with calcific pancrea~itis and group of 20 children with …
How is indican formed?
Indican is produced from tryptophan in a manner reminiscent of the production of p-cresol sulfate from tyrosine and phenylalanine. Gut bacteria convert tryptophan to indole, which is then oxidized to indoxyl and conjugated with sulfate in the liver.
What are the other tests used to determine indican in the urine?
Miscellaneous Tests These include the nitrosonaphthol test, urinary indican excretion, bacterial release of sulfapyridine from sulfasalazine, and bacterial release of paraaminobenzoic acid (PABA) from a bile salt conjugate (PABA-UDCA [ursodeoxycholic acid]).
How is indican formed in the body?
Indican is an indole produced when bacteria in the intestine act on the amino acid, tryptophan. Most indoles are excreted in the feces. The remainder is absorbed, metabolized by the liver, and excreted as indicanin the urine.
What is the other name of indican?
A potassium salt present in urine, in which it occurs as a product of the metabolism of indole. Alternative name: potassium indoxylsulphate; chemical formula C₈H₆NOSO₂OH. ‘We have studied the effect of indican on six commercial procedures for the measurement of total bilirubin in serum.
How is Indican formed?
What causes high Indican?
Excessive Indican levels are caused by poor digestion, constipation, exposure to excessive chemicals in the water, food, air, or drugs, or yeast/candida, parasites, or abnormal flora in the gut. Partially digested food may directly enter the blood, causing allergic food reactions.
What causes high indican?
What are the other tests used to determine Indican in the urine?