Does LH act on theca cells?
LH activates the LH receptor (LHR/LHCGR) in theca cells, leading to increased steroidogenesis (Cyp11a1, Cyp17a1) and androgen production. IGF1 and INSL3 enhance androgen production by LH. Androgens can then act by AR present in theca cells and fibroblasts to enhance expression of genes such as Vcam1 and Cyp17a1.
What hormone acts on theca cells?
Theca cells are stimulated by luteinizing hormone (LH), with signaling originating in the hypothalamus of the brain. Gonadotropin releasing hormone (GnRH) is released by projections of the hypothalamus into the anterior pituitary gland.
Does LH act on granulosa cells?
Luteinizing hormone acts directly at granulosa cells to stimulate periovulatory processes: modulation of luteinizing hormone effects by prostaglandins. Endocrine.
What happens in theca cells?
Theca cells function in a diverse range of necessary roles during folliculogenesis; to synthesize androgens, provide crosstalk with granulosa cells and oocytes during development, and provide structural support of the growing follicle as it progresses through the developmental stages to produce a mature and …
How does LH cause ovulation?
Ovulation. When the level of estrogen is sufficiently high, it produces a sudden release of LH, usually around day thirteen of the cycle. This LH surge (peak) triggers a complex set of events within the follicles that result in the final maturation of the egg and follicular collapse with egg extrusion.
Do theca cells have FSH receptors?
Thus even though theca cells lack FSH receptors, they nevertheless respond indirectly to FSH with increased production of the androgens required by the granulosa cells for estrogen secretion.
What does LH do for females?
In women, LH helps control the menstrual cycle. It also triggers the release of an egg from the ovary. This is known as ovulation. LH levels quickly rise just before ovulation.
Which gland secretes FSH LH?
the pituitary
Therefore, the pituitary secretes FSH and LH, a process which actually begins before the onset of your menses. These hormones in turn stimulate the growth of several ovarian follicles, each containing one egg.
What is secreted by corpus luteum?
progesterone
The primary hormone produced from the corpus luteum is progesterone, but it also produces inhibin A and estradiol.
What is theca in ovary?
Theca cells are the endocrine cells associated with ovarian follicles that play an essential role in fertility by producing the androgen substrate required for ovarian estrogen biosynthesis. Theca cells differentiate from the interfollicular stroma in response to proteins secreted from growing follicles.
What do ovarian theca cells secrete?
The theca and granulosa cells of the ovaries are the primary sources of estrogens during reproductive life. The principal and most potent estrogen secreted is 17β-estradiol (E2) but three different naturally occurring estrogens have been recognized including estrone (E1), 17β-estradiol (E2), and estriol (E3).